Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity

Abstract Enhancer RNAs (eRNAs) are a pivotal class of enhancer-derived non-coding RNAs that drive gene expression. Here we identify the SNAI1 enhancer RNA (SNAI1e; SCREEM2) as a key activator of SNAI1 expression and a potent enforcer of transforming growth factor-β (TGF-β)/SMAD signaling in cancer c...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Chuannan Fan, Qian Wang, Peter H. L. Krijger, Davy Cats, Miriam Selle, Olga Khorosjutina, Soniya Dhanjal, Bernhard Schmierer, Hailiang Mei, Wouter de Laat, Peter ten Dijke
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Online Access:	https://doi.org/10.1038/s41467-025-58032-w