Cerebrospinal fluid sTREM2 mediates the associations of α-synuclein with tau pathology in older adults without dementia: two population-based study

Abstract Background The role of microglial activation by α-synuclein in Alzheimer’s disease (AD) remains unclear. This study aimed to evaluate the role of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in regulating the relationship between α-synuclein and tau pathology in cerebro...

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Bibliographic Details
Published in:Journal of Translational Medicine
Main Authors: Yong-Chang Wang, Liang-Yu Huang, Yan-Fu, Shi-Yin Xiong, Zuo-Teng Wang, Chen-Chen Tan, Lan Tan
Format: Article
Language:English
Published: BMC 2025-07-01
Subjects:
Alzheimer’s disease
Α-synuclein
sTREM2
Microglia
APOE ε4
Tau pathology
Online Access:https://doi.org/10.1186/s12967-025-06729-3

Internet

https://doi.org/10.1186/s12967-025-06729-3

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