Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase

Macrophages exposed to the Th2 cytokines interleukin (IL) IL-4 and IL-13 exhibit a distinct transcriptional response, commonly referred to as M2 polarization. Recently, IL-4-induced polarization of murine bone marrow-derived macrophages (BMDMs) has been linked to acetyl-CoA levels through the activi...

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发表在:	Frontiers in Immunology
Main Authors:	Dmitry Namgaladze, Sven Zukunft, Frank Schnütgen, Nina Kurrle, Ingrid Fleming, Dominik Fuhrmann, Bernhard Brüne
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2018-12-01
主题:	macrophage ATP-citrate lyase acetyl-CoA interleukin-4 histone acetylation
在线阅读:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02858/full