The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR‐27a‐5p and control of UBE2N levels

Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5‐year survival rate in patients with OC is below 40%. We observed that UCA1, a lncRNA previously reported to play an oncogenic role in several malignanci...

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Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Anaïs Wambecke, Mohammad Ahmad, Pierre‐Marie Morice, Bernard Lambert, Louis‐Bastien Weiswald, Mégane Vernon, Nicolas Vigneron, Edwige Abeilard, Emilie Brotin, Martin Figeac, Pascal Gauduchon, Laurent Poulain, Christophe Denoyelle, Matthieu Meryet‐Figuiere
Format:	Article
Language:	English
Published:	Wiley 2021-12-01
Subjects:	ceRNA chemoresistance miR‐27a‐5p ovarian cancer patient‐derived organoid lncRNA UCA1
Online Access:	https://doi.org/10.1002/1878-0261.13045