Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine

Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4+ T cells. We had previously shown that intranodal vaccination with class I neoantigen pep...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Shinji Morisaki, Hideya Onishi, Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Sachiko Yoshimura, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Masafumi Nakamura, Takanari Kitazono, Takashi Morisaki
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	neoantigen neoepitope dendritic cell vaccine antigen presentation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223331/full