To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I) molecules to CD8+ T cells. They may also affect th...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Author:	Piotr Kuśnierczyk
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	ERAP2 genetics peptide trimming interactions with ERAP1 polymorphism isoforms
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.902567/full