Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway

Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads. By developing JAKs based affinity ultrafiltration method coupled with LC/Q-TOF-MS in order to discover selective JAKs i...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Yong-Qiang Tian, Dai Hu, Yong-Li Zhang, Jian Zou, Gui-Lin Chen, Ming-Quan Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	Janus kinases inhibitors total quaternary alkaloids (QAs) Zanthoxylum simulans gastric cancer (AGS) anti-proliferative activity estrogen receptors
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.922110/full