In vitro and in vivo Inhibitory Activity of NADPH Against the AmpC BER Class C β-Lactamase

β-Lactamase-mediated resistance to β-lactam antibiotics has been significantly threatening the efficacy of these clinically important antibacterial drugs. Although some β-lactamase inhibitors are prescribed in combination with β-lactam antibiotics to overcome this resistance, the emergence of enzyme...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Jung-Hyun Na, Tae Hee Lee, Soo-Bong Park, Min-Kyu Kim, Bo-Gyeong Jeong, Kyung Min Chung, Sun-Shin Cha
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-12-01
Subjects:	antimicrobial resistance class C β-lactamase AmpC BER NADPH β-lactamase inhibitors mouse infection model
Online Access:	https://www.frontiersin.org/article/10.3389/fcimb.2018.00441/full