The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications

A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials. The pre-existing immunity, the marked liver tropism and the high toxicity of first generation Ad (FG-Ad) vectors have...

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Bibliographic Details
Published in:Viruses
Main Authors: Cristian Capasso, Mariangela Garofalo, Mari Hirvinen, Vincenzo Cerullo
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Subjects:
gene therapy
adenoviral vectors
genetic modification
chimeric fibers
surface modification
pseudotyping
polymers
immunogenicity
re-targeting
Online Access:http://www.mdpi.com/1999-4915/6/2/832

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http://www.mdpi.com/1999-4915/6/2/832

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