Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors

Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-18) resulting in pyroptosis. The multi-protein composition of...

詳細記述

書誌詳細

出版年:	European Journal of Medicinal Chemistry Reports
主要な著者:	Pritam Thapa, Sunil P. Upadhyay, Vikas Singh, Varun C. Boinpelly, Jianping Zhou, David K. Johnson, Prajwal Gurung, Eung Seok Lee, Ram Sharma, Mukut Sharma
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2023-04-01
主題:	NLRP3 inflammasome Sulfonylureas Michael acceptors Chalcone NLRP3 inhibitors
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2772417422000723