A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABA<sub>B</sub>R-Coupled N-Type Calcium Channel

α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABA<sub>B</sub>R)-coupled N-type calcium channel (Ca<sub>V</sub>2.2). To improve its inhibitory activity, a series of variants were synthesized and evalua...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Yuanmei Wei, Min Zhang, Shuo Yu, Qiuyuan Huang, Rongfang Chen, Shujing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Subjects:
α-conotoxins AuIB
structure–activity relationship
GABA<sub>B</sub>R-coupled Ca<sub>V</sub>2.2
analgesic activity
Online Access:https://www.mdpi.com/1660-3397/20/12/750

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https://www.mdpi.com/1660-3397/20/12/750

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