DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer

Abstract Mitochondrial oxidative phosphorylation (OXPHOS) is a therapeutic vulnerability in glycolysis-deficient cancers. Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-de...

Full description

Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kaihong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao-Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Lake-Ee Quek, Jeff Holst, Tao Liu, Mark A. Baker, Rick F. Thorne, Xu Dong Zhang, Lei Jin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-01-01
Online Access:	https://doi.org/10.1038/s41419-025-07334-4