The locus coeruleus input to the rostral ventromedial medulla mediates stress-induced colorectal visceral pain

Abstract Unlike physiological stress, which carries survival value, pathological stress is widespread in modern society and acts as a main risk factor for visceral pain. As the main stress-responsive nucleus in the brain, the locus coeruleus (LC) has been previously shown to drive pain alleviation t...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Dexu Kong, Yunchun Zhang, Po Gao, Chao Pan, Haoyue Deng, Saihong Xu, Dan Tang, Jie Xiao, Yingfu Jiao, Weifeng Yu, Daxiang Wen
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Pathological stress Colorectal visceral pain Locus coeruleus Rostral ventromedial medulla Neural circuit
Online Access:	https://doi.org/10.1186/s40478-023-01537-6