Homogeneous antibody-drug conjugates with dual payloads: potential, methods and considerations

The development of site-specific dual-payload antibody-drug conjugates (ADCs) represents a potential advancement in targeted cancer therapy, enabling the simultaneous delivery of two distinct drugs into the same cancer cells to overcome payload resistance and enhance therapeutic efficacy. Here, we e...

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Bibliographic Details

Published in:	mAbs
Main Authors:	Miao Wen, Abigail Yu, Young Park, Daniel Calarese, Hans-Peter Gerber, Gang Yin
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Antibody drug conjugate conjugation drug resistance dual-payload homogenous manufacturability
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2498162