Pan-Cancer Analysis Shows <i>TP53</i> Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome

Previously, we have shown TGF-β-induced NOX4 expression is involved in the epithelial-to-mesenchymal transition (EMT), a process critical for cancer metastasis, and that wild-type (WT) and mutant (Mut) p53 have divergent effects on TGF-β induction of NOX4: WT-p53 suppresses whereas Mut-p53 augments...

Full description

Bibliographic Details

Published in:	Antioxidants
Main Authors:	Wei Feng Ma, Howard E. Boudreau, Thomas L. Leto
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Subjects:	NOX4 NADPH oxidase EMT p53 TCGA bioinformatics
Online Access:	https://www.mdpi.com/2076-3921/10/2/235