Direct Differentiation of Human Adult Adipose Tissue into Multilineage Functional Organoids

Current organoid-generation strategies rely predominantly on intricate in vitro manipulations of dissociated stem cells, including isolation, expansion, and genetic modification. However, these approaches present significant challenges in terms of safety and scalability for clinical applications. An...

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Bibliographic Details

Published in:	Engineering
Main Authors:	Ru-Lin Huang, Jing Yang, Yuxin Yan, Xiangqi Liu, Xiya Yin, Chuanqi Liu, Xingran Liu, Rehanguli Aimaier, Qiumei Ji, Gen Li, Tao Zan, Kang Zhang, Qingfeng Li
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Tissue regeneration Regenerative medicine Human adipose tissue Islet organoids Bone marrow organoids Neuroectoderm differentiation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095809925003595