The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure

INTRODUCTION Maladaptive hypertrophy, podocyte stress, and depletion contribute to kidney function decline. Although insulin-like growth factor 1 (IGF-1) plays a key role in early hypertrophic responses in the single kidney state, its impact on kidney transplant (KTx) outcomes remains uncertain. Thi...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Matthew Cusick, Viji Nair, Damian Fermin, John Hartman, Jeffrey A. Beamish, Zeguo Sun, Zhongyang Zhang, Edgar Otto, Rajasree Menon, Sudha Nadimidla, Nicholas Demchuk, Kelly Shaffer, Peter Heeger, Weija Zhang, Madhav C. Menon, Matthias Kretzler, Roger C. Wiggins, Abhijit S. Naik
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2025-06-01
Subjects:	Nephrology Therapeutics
Online Access:	https://doi.org/10.1172/jci.insight.188485