Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex

Chronic kidney disease (CKD) and atherosclerotic heart disease, frequently associated with dyslipidemia and hypertension, represent significant health concerns. We investigated the interplay among these conditions, focusing on the role of oxidized low-density lipoprotein (oxLDL) and angiotensin II (...

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Bibliographic Details

Published in:	eLife
Main Authors:	Jittoku Ihara, Yibin Huang, Yoichi Takami, Yoichi Nozato, Toshimasa Takahashi, Akemi Kakino, Cheng Wang, Ziwei Wang, Yu Guo, Weidong Liu, Nanxiang Yin, Ryoichi Ohara, Taku Fujimoto, Shino Yoshida, Kazuhiro Hongyo, Hiroshi Koriyama, Hiroshi Akasaka, Hikari Takeshita, Shinsuke Sakai, Kazunori Inoue, Yoshitaka Isaka, Hiromi Rakugi, Tatsuya Sawamura, Koichi Yamamoto
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-03-01
Subjects:	AT1 LOX-1 oxidized LDL angiotensin II Gq CKD
Online Access:	https://elifesciences.org/articles/98766