The Chemokine CCL5 Inhibits the Replication of Influenza A Virus Through SAMHD1 Modulation

Influenza A virus (IAV) is the main etiological agent of acute respiratory tract infections. During IAV infection, interferon triggers the overexpression of restriction factors (RFs), the intracellular antiviral branch of the innate immune system. Conversely, severe influenza is associated with an u...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Thauane Silva, Jairo R. Temerozo, Gabriele do Vale, André C. Ferreira, Vinícius Cardoso Soares, Suelen Silva Gomes Dias, Gabriela Sardella, Dumith Chequer Bou-Habib, Marilda Siqueira, Thiago Moreno L. Souza, Milene Miranda
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Subjects:	influenza restriction factors SAMHD1 CCL5/RANTES CCR5
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2021.549020/full