Reverse transcriptase inhibition potentiates target therapy in BRAF-mutant melanomas: effects on cell proliferation, apoptosis, DNA-damage, ROS induction and mitochondrial membrane depolarization

Abstract Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic landscape for metastatic melanoma patients bearing mutations in the BRAF kinase. However, the emergence of drug resistance imposes the necessity to conceive novel therapeutic strategies capable to achieve...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Luigi Fattore, Debora Malpicci, Ciro Milite, Sabrina Castellano, Gianluca Sbardella, Gerardo Botti, Paolo A. Ascierto, Rita Mancini, Gennaro Ciliberto
Format:	Article
Language:	English
Published:	BMC 2020-09-01
Subjects:	Melanoma Reverse transcriptase inhibitors Target therapy Drug resistance Mitochondrial membrane depolarization DSBs
Online Access:	http://link.springer.com/article/10.1186/s12964-020-00633-7