Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model

Down syndrome (DS) is the most common condition with intellectual disability and is caused by trisomy of Homo sapiens chromosome 21 (HSA21). The increased dosage of genes on HSA21 is associated with early neurodevelopmental changes and subsequently at adult age with the development of Alzheimer-like...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Chiara Lanzillotta, Monika Rataj Baniowska, Francesca Prestia, Chiara Sette, Valérie Nalesso, Marzia Perluigi, Eugenio Barone, Arnaud Duchon, Antonella Tramutola, Yann Herault, Fabio Di Domenico
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Down syndrome Mouse model Aging Cognitive decline Neurodegeneration Brain metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996124001220