Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined. Here, we observed a marked reduction in acinar GPX4 expression and ferroptotic cell death in mice wi...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Xiaojie Ma, Xiaowu Dong, Yao Xu, Nan Ma, Mei Wei, Xiaochun Xie, Yingying Lu, Wangsen Cao, Guotao Lu, Weiqin Li
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	acute pancreatitis ferroptosis active protein 1 transcription factor GPX4
Online Access:	https://www.mdpi.com/2076-3921/12/1/100