Medical Biology of Cancer-Associated Fibroblasts in Pancreatic Cancer

Pancreatic cancer is one of the deadliest forms of cancer with one of the lowest 5-year survival rates of all cancer types. A defining characteristic of pancreatic cancer is the existence of dense desmoplastic stroma that, when exposed to stimuli such as cytokines, growth factors, and chemokines, ge...

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Bibliographic Details

Published in:	Biology
Main Authors:	Annah Morgan, Michelle Griffin, Lionel Kameni, Derrick C. Wan, Michael T. Longaker, Jeffrey A. Norton
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	cancer-associated fibroblasts (CAFs) pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) extracellular matrix (ECM) heterogeneity metastasis
Online Access:	https://www.mdpi.com/2079-7737/12/8/1044