Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

Abstract Accumulating evidence suggests that type I interferon (IFN-I) signaling is a key contributor to immune cell-mediated neuropathology in neurodegenerative diseases. Recently, we demonstrated a robust upregulation of type I interferon-stimulated genes in microglia and astrocytes following expe...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Acta Neuropathologica Communications
المؤلفون الرئيسيون:	Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru Peterson, Madison R. Mix, John T. Harty, Thomas Nickl-Jockschat, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2023-08-01
الموضوعات:	Traumatic brain injury Type I interferon Neuroinflammation Neurodegeneration Microglia Neuroimmune
الوصول للمادة أونلاين:	https://doi.org/10.1186/s40478-023-01635-5