VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer in vivo

Objective: We aimed to develop a novel anti-HIF-1α intrabody to decrease gemcitabine resistance in pancreatic cancer patients. Methods: Surface plasmon resonance and glutathione S-transferase pull-down assays were conducted to identify the binding affinity and specificity of anti-HIF-1α VHH212 [a si...

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Bibliographic Details

Published in:	Cancer Biology & Medicine
Main Authors:	Guangbo Kang, Min Hu, He Ren, Jiewen Wang, Xin Cheng, Ruowei Li, Bo Yuan, Yasmine Balan, Zixuan Bai, He Huang
Format:	Article
Language:	English
Published:	China Anti-Cancer Association 2021-08-01
Subjects:	pancreatic cancer nanobody therapeutic intracellular antibody hif-1α inhibitor gemcitabine chemosensitizer
Online Access:	http://www.cancerbiomed.org/index.php/cocr/article/view/1837