Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

Pharmaceutical companies routinely screen compounds for hemodynamics related safety risk. In vitro secondary pharmacology is initially used to prioritize compounds while in vivo studies are later used to quantify and translate risk to humans. This strategy has shown limitations but could be improved...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Christopher J. Morris, Michael G. Rolf, Linda Starnes, Inmaculada C. Villar, Amy Pointon, Holly Kimko, Giovanni Y. Di Veroli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	hemodynamic drug safety clinical translation quantitative systems toxicology rat dog secondary pharmacology
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1402462/full