Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson’s Disease

Oxymatrine (OMT), a natural quinoxaline alkaloid extracted from the root of Sophora flavescens, presents amounts of pharmacological properties including immunomodulation, anti-inflammation, anti-oxidation, and anti-virus. Recent studies tend to focus on its effects on neuroinflammation and neuroprote...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Ping Gan, Lidong Ding, Guihua Hang, Qiaofang Xia, Zhimei Huang, Xing Ye, Xiaojuan Qian
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-05-01
Subjects:	Parkinson’s disease oxymatrine neuroinflammation microglia neuroprotection cathepsin D
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00776/full