A toxin-antitoxin system provides phage defense via DNA damage and repair

Abstract Widespread in bacteria and archaea, toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosylt...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Huan Pu, Yuxin Chen, Xinjun Zhao, Lunzhi Dai, Aiping Tong, Dongmei Tang, Qiang Chen, Yamei Yu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Online Access:	https://doi.org/10.1038/s41467-025-58540-9