Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis

Abstract Background Neuropathic pain involves neuroinflammation and upregulation of glycolysis in the central nervous system. Unfortunately, few effective treatments are available for managing this type of pain. The overactivation of lactate dehydrogenase A (LDHA), an essential enzyme in glycolysis,...

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Bibliographic Details

Published in:	The Journal of Headache and Pain
Main Authors:	Hao-Jung Cheng, Nan-Fu Chen, Wu-Fu Chen, Zong-Sheng Wu, Yu-Yo Sun, Wei-Nung Teng, Fu-Wei Su, Chun-Sung Sung, Zhi-Hong Wen
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Neuropathic pain Lactate dehydrogenase A Neuroinflammation Angiogenesis
Online Access:	https://doi.org/10.1186/s10194-024-01916-x