Peptide Blockers of PD-1-PD-L1 Interaction Reinvigorate PD-1-Suppressed T Cells and Curb Tumor Growth in Mice

The programmed cell death protein 1 (PD-1) plays a critical role in cancer immune evasion. Blocking the PD-1-PD-L1 interaction by monoclonal antibodies has shown remarkable clinical efficacy in treating certain types of cancer. However, antibodies are costly to produce, and antibody-based therapies...

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Bibliographic Details

Published in:	Cells
Main Authors:	Shanshan (Jenny) Zhong, Xiaoling Liu, Tomonori Kaneko, Yan Feng, Owen Hovey, Kyle Yang, Sally Ezra, Soon-Duck Ha, Sung Kim, John K. McCormick, Huadong Liu, Shawn Shun-Cheng Li
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	programmed cell death-1 (PD-1) PD-1 ligand-1 (PD-L1) immune checkpoint blockade PD-1/PD-L1 blocking peptide peptide-based immunomodulator
Online Access:	https://www.mdpi.com/2073-4409/13/14/1193