A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility

DEPDC5 is a newly identified epilepsy-related gene implicated in focal epilepsy, brain malformations, and Sudden Unexplained Death in Epilepsy (SUDEP). In vitro, DEPDC5 negatively regulates amino acid sensing by the mTOR complex 1 (mTORC1) pathway, but the role of DEPDC5 in neurodevelopment and epil...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Christopher J. Yuskaitis, Brandon M. Jones, Rachel L. Wolfson, Chloe E. Super, Sameer C. Dhamne, Alexander Rotenberg, David M. Sabatini, Mustafa Sahin, Annapurna Poduri
Format:	Article
Language:	English
Published:	Elsevier 2018-03-01
Subjects:	DEPDC5 Focal cortical dysplasia mTOR Familial focal epilepsy Seizures Conditional knockout
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996117302942