Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial

Summary: Within the penile microbiome, bacteria associated with seroconversion, immunology, and cells (BASIC species) enhance HIV susceptibility in heterosexual uncircumcised men by inducing foreskin inflammation and HIV target cell recruitment. This phase 1/2 clinical trial randomizes HIV-uninfecte...

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Bibliographic Details

Published in:	Cell Reports Medicine
Main Authors:	Ronald M. Galiwango, Brenda Okech, Daniel E. Park, Lane Buchanan, Zhongtian Shao, Bernard Bagaya, Juliet Mpendo, Vineet Joag, Sergey Yegorov, Annet Nanvubya, Victoria M. Biribawa, Teddy Namatovu, Charles Kato, Barbara Kawoozo, Ali Ssetaala, Moses Muwanga, Maliha Aziz, Tony Pham, Sanja Huibner, Aaron A.R. Tobian, Cindy M. Liu, Jessica L. Prodger, Rupert Kaul
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	HIV transmission penile microbiome clinical trial antimicrobials Uganda genital immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666379124004269