Comparison of tumor and two types of paratumoral tissues highlighted epigenetic regulation of transcription during field cancerization in non-small cell lung cancer

Abstract Background Field cancerization is the process in which a population of normal or pre-malignant cells is affected by oncogenic alterations leading to progressive molecular changes that drive malignant transformation. Aberrant DNA methylation has been implicated in early cancer development in...

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Bibliographic Details

Published in:	BMC Medical Genomics
Main Authors:	Qiushi Wang, Libo Wu, Jiaxing Yu, Guanghua Li, Pengfei Zhang, Haozhe Wang, Lin Shao, Jinying Liu, Weixi Shen
Format:	Article
Language:	English
Published:	BMC 2022-03-01
Subjects:	NSCLC Field cancerization DNA methylation Bisulfite sequencing Epigenetics
Online Access:	https://doi.org/10.1186/s12920-022-01192-1