Association of NF-κB and AP-1 with MMP-9 Overexpression in 2-Chloroethanol Exposed Rat Astrocytes

Subacute poisoning of 1,2-dichloroethane (1,2-DCE) has become a serious occupational problem in China, and brain edema is its main pathological consequence, but little is known about the underlying mechanisms. As the metabolite of 1,2-DCE, 2-chloroethanol (2-CE) is more reactive, and might play an i...

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Bibliographic Details

Published in:	Cells
Main Authors:	Tong Wang, Xiaoxia Jin, Yingjun Liao, Qi Sun, Chaohong Luo, Gaoyang Wang, Fenghong Zhao, Yaping Jin
Format:	Article
Language:	English
Published:	MDPI AG 2018-08-01
Subjects:	1,2-Dichloroethane poisoning 2-Chloroethanol matrix metalloproteinases-9 p38 MAPK signal pathway nuclear factor-κB activator protein-1
Online Access:	http://www.mdpi.com/2073-4409/7/8/96