APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice

Abstract The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astroglial function, which exert multiple effects on AD pathogenesis. Here, we show...

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Bibliographic Details
Published in:Journal of Neuroinflammation
Main Authors: T. L. Stephen, B. Breningstall, S. Suresh, C. J. McGill, C. J. Pike
Format: Article
Language:English
Published: BMC 2022-12-01
Subjects:
Alzheimer’s disease
Apolipoprotein E
Astrocytes
Glial interactions
Sex
Online Access:https://doi.org/10.1186/s12974-022-02650-4

Internet

https://doi.org/10.1186/s12974-022-02650-4

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