Single-Dose Intranasal or Intramuscular Administration of Simian Adenovirus-Based H1N1 Vaccine Induces a Robust Humoral Response and Complete Protection in Mice

Despite the widespread accessibility of vaccines and antivirals, seasonal influenza virus epidemics continue to pose a threat to public health. In this study, we constructed a recombinant replication-deficient simian adenovirus type 25 vector carrying the full-length hemagglutinin (HA) of the H1N1 i...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Daria V. Voronina, Irina V. Vavilova, Olga V. Zubkova, Tatiana A. Ozharovskaia, Olga Popova, Anastasia S. Chugunova, Polina P. Goldovskaya, Denis I. Zrelkin, Daria M. Savina, Irina A. Favorskaya, Dmitry V. Shcheblyakov, Denis Y. Logunov, Alexandr L. Gintsburg
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	SAd25 ChAd68 adenoviral vector influenza H1N1 humoral immunity
Online Access:	https://www.mdpi.com/1999-4915/17/8/1085