Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) infection of macrophages reprograms cellular metabolism to promote lipid retention. While it is clearly known that intracellular Mtb utilize host-derived lipids to maintain infection, the role of macrophage lipid processing on the bacteria’s ability to access the int...

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Bibliographic Details

Published in:	eLife
Main Authors:	Nelson V Simwela, Eleni Jaecklein, Christopher M Sassetti, David G Russell
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-03-01
Subjects:	tuberculosis mycobacterium macrophage lipid metabolism
Online Access:	https://elifesciences.org/articles/102980