Molecular Biophysics of Class A G Protein Coupled Receptors–Lipids Interactome at a Glance—Highlights from the A_2A Adenosine Receptor

G protein-coupled receptors (GPCRs) are embedded in phospholipid membrane bilayers with cholesterol representing 34% of the total lipid content in mammalian plasma membranes. Membrane lipids interact with GPCRs structures and modulate their function and drug-stimulated signaling through conformation...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Efpraxia Tzortzini, Antonios Kolocouris
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	A<sub>2A</sub> adenosine receptor cholesterol coarse graining GPCR molecular dynamics PIP<sub>2</sub>
Online Access:	https://www.mdpi.com/2218-273X/13/6/957