Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s

ABSTRACT Antibody responses to variant surface antigens (VSAs) produced by the malaria parasite Plasmodium falciparum may contribute to age-related natural immunity to severe malaria. One VSA family, P. falciparum erythrocyte membrane protein-1 (PfEMP1), includes a subset of proteins that binds endo...

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Bibliographic Details

Published in:	mSphere
Main Authors:	Madison A. Tewey, Drissa Coulibaly, Jonathan G. Lawton, Emily M. Stucke, Albert E. Zhou, Andrea A. Berry, Jason A. Bailey, Andrew Pike, Antoine Dara, Amed Ouattara, Kirsten E. Lyke, Olukemi Ifeonu, Matthew B. Laurens, Matthew Adams, Shannon Takala-Harrison, Amadou Niangaly, Bourema Kouriba, Abdoulaye K. Koné, J. Alexandra Rowe, Ogobara K. Doumbo, Jigar J. Patel, John C. Tan, Philip L. Felgner, Christopher V. Plowe, Mahamadou A. Thera, Mark A. Travassos
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-10-01
Subjects:	Malaria Plasmodium falciparum PfEMP1 variant surface antigen CIDRα1 endothelial protein C receptor
Online Access:	https://journals.asm.org/doi/10.1128/msphere.00451-23