Tethered Antigenic Suppression Shields the Hemagglutinin Head Domain and Refocuses the Antibody Response to the Stalk Domain

Influenza has been a global health concern for the past century. Current seasonal influenza vaccines primarily elicit an antibody response that targets the immunodominant head domain of the viral glycoprotein hemagglutinin (HA), which consistently mutates due to selective pressure. To circumvent thi...

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Bibliographic Details

Published in:	Chemistry
Main Authors:	Donguk Kim, Kathryn Loeffler, Yixin Hu, Ammar Arsiwala, Steven Frey, Shruthi Murali, Vivek Hariharan, Alberto Moreno, Ravi S. Kane
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Subjects:	vaccine antigenic suppression immune refocusing
Online Access:	https://www.mdpi.com/2624-8549/7/1/12