Regulatory role of N-nitroso compounds and lncRNA NEAT1 in endoplasmic reticulum stress and malignant transformation of gastric epithelial cells

Abstract This study investigates the early oncogenic transformation of gastric epithelial cells (GES-1) and adenocarcinoma cells (AGS) following long-term exposure to N-nitroso compounds (NOCs), using N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) as a model carcinogen. Prolonged MNNG treatment enhance...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Xing Liu, Yichun Zhao, Yueyue Zhou, Xihuan Zou, Ruobing Chen, Yuting Peng, Meng Yu
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	N-nitroso compounds Endoplasmic reticulum stress NEAT1 MiR-329-3p Gastric cancer
Online Access:	https://doi.org/10.1186/s12935-025-03954-0