Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging

Abstract The most common malignant brain tumour in children, medulloblastoma (MB), is subdivided into four clinically relevant molecular subgroups, although targeted therapy options informed by understanding of different cellular features are lacking. Here, by comparing the most aggressive subgroup...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Franziska Linke, James E. C. Johnson, Stefanie Kern, Christopher D. Bennett, Anbarasu Lourdusamy, Daniel Lea, Steven C. Clifford, Catherine L. R. Merry, Snow Stolnik, Morgan R. Alexander, Andrew C. Peet, David J. Scurr, Rian L. Griffiths, Anna M. Grabowska, Ian D. Kerr, Beth Coyle
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Subjects:	Medulloblastoma Group 3 SHH Tricarboxylic acid (TCA) cycle Small leucine-rich proteoglycans (SLRPs)
Online Access:	https://doi.org/10.1186/s40478-022-01496-4