Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis

Abstract Background β-Secretase (BACE1) is the vital enzyme in the pathogenic processes of Alzheimer's disease (AD). However, the development of a powerful tool with sensitivity for BACE1 determination in vivo is a challenge. Methods A novel NIR fluorescent probe HBAE was synthetized from 2-hyd...

Full description

Bibliographic Details

Published in:	Biomaterials Research
Main Authors:	Anyao Bi, Junyong Wu, Shuai Huang, Yongjiang Li, Fan Zheng, Jipeng Ding, Jie Dong, Daxiong Xiang, Wenbin Zeng
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science (AAAS) 2022-12-01
Subjects:	Alzheimer’s disease Fluorescent probe Near-infrared fluorescence imaging BACE1 Materials imaging in vivo
Online Access:	https://doi.org/10.1186/s40824-022-00320-3