Demystifying the Relationship Between Metformin, AMPK, and Doxorubicin Cardiotoxicity

Doxorubicin (DOX) is an extremely effective and wide-spectrum anticancer drug, but its long-term use can lead to heart failure, which presents a serious problem to millions of cancer survivors who have been treated with DOX. Thus, identifying agents that can reduce DOX cardiotoxicity and concurrentl...

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Bibliographic Details
Published in:Frontiers in Cardiovascular Medicine
Main Authors: Manrose Singh, Akito T. Nicol, Jaclyn DelPozzo, Jia Wei, Mandeep Singh, Tony Nguyen, Satoru Kobayashi, Qiangrong Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Subjects:
doxorubicin
metformin
AMPK
doxorubicin cardiotoxicity
cardio-oncology
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.839644/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.839644/full

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