From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression

Metabolic reprogramming and epigenetic modification have been widely observed in cancer research. Based on accumulating experimental evidence in recent years, beginning with metabolic reprogramming driven by carcinogenic signals, the accumulation of key metabolites, represented by lactate, continuou...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yi Li, Lu Feng, Qian Shen, Xiaochen Jiang, Fudong Liu, Chuanlong Zhang, Runzhi Qi, Bo Pang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	metabolic reprogramming epigenetic modification histone lactylation tumor targeted therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542664/full