IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production

The influenza virus is a cause of seasonal epidemic disease and enormous economic injury. The best way to control influenza outbreaks is through vaccination. The Madin-Darby canine kidney cell line (MDCK) is currently approved to manufacture influenza vaccines. However, the viral load from cell-base...

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Bibliographic Details

Published in:	PeerJ
Main Authors:	Oraphan Mayuramart, Witthaya Poomipak, Somruthai Rattanaburi, Kritsada Khongnomnan, Songtham Anuntakarun, Suthat Saengchoowong, Tanit Chavalit, Naphat Chantaravisoot, Sunchai Payungporn
Format:	Article
Language:	English
Published:	PeerJ Inc. 2022-09-01
Subjects:	CRISPR-Cas9 IRF7 MDCK Influenza Interferon Vaccine production
Online Access:	https://peerj.com/articles/13989.pdf