Dishevelled 2 regulates cancer cell proliferation and T cell mediated immunity in HER2-positive breast cancer

Abstract Background Dishevelled paralogs (DVL1, 2, 3) are key mediators of Wnt pathway playing a role in constitutive oncogenic signaling influencing the tumor microenvironment. While previous studies showed correlation of β-catenin with T cell gene expression, little is known about the role of DVL2...

Full description

Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Fahmida Rasha, Geetha Priya Boligala, Mingxiao V. Yang, Dalia Martinez-Marin, Isabel Castro-Piedras, Kathryn Furr, Annie Snitman, Sonia Y. Khan, Luis Brandi, Maribel Castro, Hafiz Khan, Nusrat Jahan, Sharilyn Almodovar, Michael W. Melkus, Kevin Pruitt, Rakhshanda Layeequr Rahman
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	Breast cancer Dishevelled HER2 Tumor infiltrating lymphocytes Wnt signaling
Online Access:	https://doi.org/10.1186/s12885-023-10647-2