BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving endoplasmic reticulum stress in mice with MASH

Abstract Background and aims Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases worldwide, and specific treatment modalities are lacking. Accumulating evidence suggests that hepatic inflammation plays a key role in the progression from hepatic st...

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書誌詳細

出版年:	Molecular Medicine
主要な著者:	Yi Chen, Kangjie Xie, Caiyang Chen, Xihui Wang, Chenchen Ma, Zhangxiang Huang, Yingfu Jiao, Weifeng Yu
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-05-01
主題:	Bone marrow-derived macrophages Endoplasmic reticulum stress Extracellular vesicles Lipotoxicity Metabolic dysfunction-associated steatohepatitis
オンライン･アクセス:	https://doi.org/10.1186/s10020-025-01275-6