The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

Abstract Background The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino acids across the plasma membrane. While LAT1 is overexpressed in a variety of human neoplasms, its expression and its role in thyroid cancer is currently unknown. Anaplastic thyroid carcinoma (ATC) is a...

詳細記述

書誌詳細

出版年:	Journal of Experimental & Clinical Cancer Research
主要な著者:	Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch, Roch-Philippe Charles
フォーマット:	論文
言語:	英語
出版事項:	BMC 2018-09-01
主題:	Genetically engineered mice ATC BRAF SLC7A5 mTOR
オンライン･アクセス:	http://link.springer.com/article/10.1186/s13046-018-0907-z