Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Abstract Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathologic...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Online Access:	https://doi.org/10.1038/s41467-024-49402-x